Prilosec and Synthroid Interactions

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum. Improves overall quality of life by alleviating discomfort caused by acid-related conditions. Omeprazole and pantoprazole should be given on an empty stomach 60 minutes before the first meal of the day. This section collects any data citations, data availability statements, or supplementary materials included in this article. If you do experience frequent heartburn or GI symptoms, it might be a good idea to schedule an appointment and follow up with your physician.

• Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.
• The GRADE quality of evidence suggested that there was moderate quality of evidence in the included studies (Supplementary Table S4).
• We know that some gastrointestinal conditions can affect the levothyroxine absorption; for example, celiac disease and inflammatory bowel disease.
• Nevertheless, as they are all thyroid hormones, and have similar absorption properties, they are generally included with levothyroxine as far as interactions are concerned.
• It is important to work closely with your healthcare provider to ensure that these medications are appropriate for you and that they are taken in a way that maximizes their benefits while minimizing any potential risks.

Effective Acid Reduction

Omeprazole and pantoprazole are proton pump inhibitors, most commonly used for gastroesophageal reflux disease (GERD), ulcers, and other gastric hypersecretory conditions. Each of the included studies showed an increase in TSH levels following LT4 and PPI consumption and in the majority of these, the increase was statistically significant. This effect could be much evident in subjects in whom LT4 absorption is already impaired for other reasons. However, this finding should be interpreted with caution due to the limited number of studies with relatively short follow-up period and lack of robust statistical evidence. Well-designed large studies are needed in order to further better clarify the interfering role of PPI on LT4 intestinal absorption. Regarding the quality assessment, six out of seven studies were considered at low risk of bias,25–28,31,38 while one37 was considered at moderate risk because of measurement of outcomes.

• Monitor TSH levels closely and adjust levothyroxine doses as necessary during concomitant use .
• Indeed, serum TSH levels were lower under the oral solution compared with the tablet both in the replacement group (1.7 mU/l ± 1.0 vs. 5.4 mU/l ± 4.3) and in the TSH-suppressive group (0.1 mU/l ± 0.3 vs. 2.1 mU/l ± 2.7).
• A title and abstract review was performed on the remaining 2004 studies, with 1983 excluded at this first stage for not meeting the PICOS criteria.
• Individual drug-drug interaction detail pages contain references specific to that interaction.
• These foods should be avoided within several hours of dosing if possible.

A. There is a strong likelihood that the PPI (proton pump inhibitor) you are taking for acid reflux is interfering with absorption of your thyroid medicine (Clinical Drug Investigation, March 2015). One brand of levothyroxine, Tirosint, is liquid that can be taken in a gelcap or as a liquid (Tirosint-SOL). Since the liquid form does not need to be dissolved, then the effect of PPIs on levothyroxine absorption should be minimal.

Major

Embryofetal and postnatal developmental toxicities were observed in offspring of parents given at least 3.4 times an oral human dose of 40 mg. Using multivitamin with minerals together with levothyroxine may decrease the effects of levothyroxine. You should separate the administration of levothyroxine and multivitamin with minerals by at least 4 hours. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. With hypothyroidism, you do not produce enough thyroid hormone and must replace it. The effectiveness of levothyroxine therapy is measured by monitoring your symptoms and by checking the amount of two key thyroid-related hormones, thyroid stimulating hormone and T4, in the blood.

There was a considerable heterogeneity among the included studies in design, sample size, inclusion and exclusion criteria, treatment regimen, and baseline demographics. Each of the included studies showed an increase in TSH levels following LT4 and PPI consumption, and in the majority of these, the increase was statistically significant. I want to point out that moststudies have researched the effects of PPIs and levothyroxine specifically, not necessarily Cytomel and Nature-Throid.

You may have even heard that you should not take your levothyroxine (Euthyrox, Levothroid, synthroid vitex Levoxyl, Synthroid, Unithroid) with coffee. Just be sure to take the levothyroxine consistently at the same time and the same way. The results were supplemented by a manual search of the bibliographies of the shortlisted review and original study articles.

Consult Your Healthcare Provider

In this study, the authors wanted to find out if PPIs affect the absorption of liquid levothyroxine (Tirosint- SOL). It’s commonly prescribed to treat gastroesophageal reflux disease or a host of other stomach conditions. Proton pump inhibitors alter the acidity of the stomach, something which studies have shown can decrease the absorption of thyroid hormone prescription products. There is a potential interaction between any proton pump inhibitor (e.g. Prilosec (omeprazole)) and most medications used to treat hypothyroidism (such as Cytomel (liothyronine) and Nature-Throid). In our latest question and answer, the pharmacist discusses the interaction between proton pump inhibitors, like omeprazole, and thyroid medication. The relevance of a particular drug interaction to a specific individual is difficult to determine.

Indeed, serum TSH levels were lower under the oral solution compared with the tablet both in the replacement group (1.7 mU/l ± 1.0 vs. 5.4 mU/l ± 4.3) and in the TSH-suppressive group (0.1 mU/l ± 0.3 vs. 2.1 mU/l ± 2.7). Proton pump inhibitors, when taken consistently, have a long duration of action. They can alter the stomach acid for well over 24 hours after dosing (which is why they are generally dosed on daily). So, unfortunately, taking, say, omeprazole in the morning and your thyroid medications in the evening, won’t do much good.

Of 887 patients who had been on a stable levothyroxine dose for at least 2 years prior to initiation of a proton pump inhibitor, 5.6% had a 5 milliunit/L or greater increase in TSH . When these two medications are taken together, there can be potential interactions that affect the absorption and effectiveness of both drugs. Levothyroxine, for example, may have reduced absorption when taken with Prilosec, leading to decreased thyroid hormone levels in the body. This can result in symptoms of hypothyroidism such as fatigue, weight gain, and depression. Prilosec, also known as omeprazole, is a proton pump inhibitor (PPI) medication used to treat conditions such as gastroesophageal reflux disease (GERD), ulcers, and inflammation of the esophagus. Prilosec works by reducing the production of stomach acid, which helps alleviate symptoms like heartburn, acid reflux, and indigestion.

How long after taking levothyroxine can you drink milk?

You can click on the reference number within brackets ” to see what reference was utilized. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Prilosec is designed to provide long-lasting relief from stomach-related issues, allowing individuals to experience symptom reduction over an extended period of time. One of the main advantages of using Prilosec is its effectiveness in treating various digestive issues.